This elaborate Baroque monument set against the third pillar of the south aisle has several peculiarities. It is crowned by the coat-of-arms of Pope Nicholas IV (Girolamo Masci) who is actually buried in the Basilica of Santa Maria Maggiore. This memorial was built for his late descendant, Count Masci-Ferracuti from Ascoli Piceno who was appointed to the Bishop of Vieste by Pope Sixtus V in 1589. He died in Rome in 1613 at the age of 60 years. The tomb was built by his niece, Anastasia Mascia and her husband, Marzio Elefantucci, a nobleman from Bologna. Under the pretense of honoring their uncle they built a monument for the most illustrious member of their family, Pope Nicholas IV whose name is mentioned twice in the funerary inscription.

There is another inscription on the base with the symbol of two crossbones under the guard of a winged angel. The rather macabre Latin verse speaks about a child who died while his mother was shedding too many tears at the tomb of her uncle.