The painting is one of the most famous works by Antoniazzo Romano, executed in 1500, several years after the death of Torquemada. The Cardinal is represented in the altarpiece kneeling at the feet of the Virgin together with the children for whom the charitable institute he had founded operated. Torquemada's confraternity was responsible for one of the Dominicans' most famous charitable works in Rome, the provision of dowries for poverty-stricken young women.